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KMID : 1094720230280040000
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Biotechnology and Bioprocess Engineering
2023 Volume.28 No. 4 p.0 ~ p.0
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Schisandrae Fructus Ameliorates Topical Particulate Matter 2.5-induced Keratoconjunctivitis Sicca That Are Accompanied by Retinal and Lipid Metabolism Disorders
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Lee Hye-sook
Hwangbo Hyun
Kim Da-Hye
Kim Min-Yeong
Ji Seon-Yeong
Hong Su-Hyun
Park Cheol
Kwon Chan-Young
Leem Sun-Hee
Kim Gi-Young
Choi Yung-Hyun
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Abstract
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Particulate matter 2.5 (PM2.5) is the biological toxic substances in the air pollutants, and causes to dry eye disease. To date, studies on the development of treatment for PM2.5-mediated dry eye disease are extremely limited. Schisandrae Fructus (SF), the fruit of Schisandra chinensis Turcz. (Baillon), has been used as traditionally herbal medicine in Northeastern Asia. SF has various pharmacological effects, but its effect on the ocular system have not been well defined. The aim of the present study was to investigate the effect of SF ethanol extract (SFE) on topical PM2.5-mediated dry eye symptoms in rats. SFE ameliorated tear deficiency, corneal epithelium detachment, reduction of conjunctival goblet cell, and inflammation of cornea and lacrimal gland induced by PM2.5 exposure. In addition, SFE markedly suppressed PM2.5-induced changes in the retinal composition, including loss of ganglion cells. Furthermore, oral administration of SFE significantly restrained PM2.5-induced increasing levels of total cholesterol and low low-density lipoprotein cholesterol. In conclusion, oral application of SFE may have protective effects against dry eye disease by PM2.5 exposure that result from restoration of tear film and inhibition of inflammation, and may in part contribute to improvement of retinal disorder and dyslipidemia.
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KEYWORD
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dry eye disease, inflammation, lipid metabolism, particulate matter, Schisandrae Fructus
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